Hereditary nonpolyposis colorectal cancer HNPCC is very often caused by a defective MSH2 gene leading to defective mismatch repairbut displays no symptoms of "accelerated aging".
Debate concerning "accelerated aging"[ edit ] Some biogerontologists question that such a thing as "accelerated aging" actually exists, at least partly on the grounds that all of the so-called accelerated aging diseases are segmental progerias. Many disease conditions such as diabeteshigh blood pressureetc. Without reliable biomarkers of aging it is hard to support the claim that a disease condition represents more than accelerated mortality.
It is further argued that segmental aging phenotype is a natural part of aging insofar as genetic variation leads to some people being more disposed than others to aging-associated diseases such as cancer and Alzheimer's disease.
Then the repair 11 oxo zsírvesztés will likely be deficient, and, as a consequence, damages will tend to accumulate.
Germ-line DNA repair mutations that increase the risk of cancer are listed in the Table.